8.51090

TFFH

Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem^®

• 同義詞: TFFH, Tetramethylfluoroformamidinium hexafluorophosphate,Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate
• 經驗公式（希爾表示法）: C₅H₁₂F₇N₂P
• CAS號碼: 164298-23-1
• 分子量：: 264.12
• MDL號碼: MFCD02684443
• 分類程式碼代碼: 12352107
• NACRES: NA.22

屬性

• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: solid
• 反應適用性: reaction type: Coupling Reactions
• 製造商／商標名: Novabiochem^®
• mp: 104-109 °C
• 應用: peptide synthesis
• 儲存溫度: 2-8°C
• InChI: 1S/C5H12FN2/c1-7(2)5(6)8(3)4/h1-4H3/q+1
• InChI 密鑰: JILUGXGJYPRQPA-UHFFFAOYSA-N

描述

一般說明

TFFH is an in situ coupling reagents which smoothly converts protected amino acids to the corresponding acid fluoride in the presence of base ^[1]. Acid fluorides have proven are highly effective at coupling hindered amino acids such as α,α-disubstituted amino acids ^[2].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] L. A. Carpino, et al. (1995) J. Am. Chem. Soc., 117, 5401.
^[2] S. A. Triolo, et al. in ′Peptides 1996, Proc. of 24th European Peptide Symposium′, R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 839.

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay 1H-qNMR: ≥ 98.0 %
Ratio Cation/anion in 19F-NMR integration: lot specific result
1:5,7 to 1:6,3
Identity (IR): passes test

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H315 - H318 - H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable