613551

TMEM16A Inhibitor, T16Ainh-A01

The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.

• 同義詞: TMEM16A Inhibitor, T16Ainh-A01, ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
• 經驗公式（希爾表示法）: C₁₉H₂₀N₄O₃S₂
• CAS號碼: 552309-42-9
• 分子量：: 416.52
• MDL號碼: MFCD03278952
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 100 mg/mL, clear, colorless
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: [s]1c(nc(c1)c3ccc(cc3)OC)NC(=O)CSc2[nH][c](c(c(n2)C)CC)=O
• InChI: 1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
• InChI 密鑰: QSIYTNYMBWYHAA-UHFFFAOYSA-N

描述

一般說明

An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC₅₀ = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Davis, A.J., et al. 2012 Br. J. Pharmacol.,in press
Namkung, W., et al. 2011., J Biol Chem. in press.
Namkung, W., et al. 2011., FASEB J. in press.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable