推薦產品
品質等級
化驗
≥98% (TLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated
顏色
white to off-white
溶解度
methanol: 20 mg/mL
water: 50 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16?,18+,22+;;/m0../s1
InChI 密鑰
MKSVFGKWZLUTTO-USYAMCSGSA-N
一般說明
原核和真核蛋白质合成抑制剂。类似于氨酰tRNA的氨酰腺苷酸末端相似的核苷，与大核糖体亚单位的“A位点”竞争结合。其掺入生长中的多肽，导致链延伸终止和新生多肽基嘌呤霉素的释放。用于选择表达转染pac基因（白黑链霉菌）的哺乳动物细胞系，其产物嘌呤霉素乙酰转移酶通过乙酰化使药物失活。诱导胸腺细胞和HL-60白血病细胞内DNA断裂。与放线菌酮一样，嘌呤霉素也被用作多种细胞分析中的通用蛋白质合成抑制剂。
嘌呤霉素二盐酸盐，CAS 58-58-2，是一种氨基核苷抗生素，通过阻断翻译步骤抑制蛋白质合成，并引起新生多肽链过早释放。
蛋白质合成抑制剂。通过导致新生多肽链过早释放来抑制翻译。诱导胸腺细胞和HL-60白血病细胞内DNA断裂。
生化／生理作用
首要靶标
蛋白质合成
蛋白质合成
警告
毒性：有害（C）
重構
复溶后，通过0.22 µm孔径的过滤器过滤灭菌，等分并冷冻（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他說明
Chow, S.C., et al. 1995.Exp.Cell Res. 216, 149.
Constam, D.B., et al. 1995.J. Biol. Chem.270, 26931.
Wirth, M., et al. 1994.J. Virol.68, 566.
Claeyssens, S., et al. 1993.FEBS Lett.315, 7.
Hechler, U., et al. 1993.Biochem.Biophys.Res. Commun.194, 1305.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
de la Luna, S. and Ortín, J. 1992.Methods Enzymol.216, 376.
Kalpaxis, D.L. and Drainas, D. 1992.Arch.Biochem.Biophys.300, 629.
Shipston, M.J. and Antoni, F.A.1992.Biochem.Biophys.Res. Commun.189, 1382.
Constam, D.B., et al. 1995.J. Biol. Chem.270, 26931.
Wirth, M., et al. 1994.J. Virol.68, 566.
Claeyssens, S., et al. 1993.FEBS Lett.315, 7.
Hechler, U., et al. 1993.Biochem.Biophys.Res. Commun.194, 1305.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
de la Luna, S. and Ortín, J. 1992.Methods Enzymol.216, 376.
Kalpaxis, D.L. and Drainas, D. 1992.Arch.Biochem.Biophys.300, 629.
Shipston, M.J. and Antoni, F.A.1992.Biochem.Biophys.Res. Commun.189, 1382.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Rui Chen et al.
BMC medicine, 20(1), 68-68 (2022-02-17)
Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson's disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in PD pathogenesis remain major challenges. To identify the potential
Hong-Yan Chen et al.
Helicobacter, 26(6), e12849-e12849 (2021-09-08)
Activin A receptor type I (ACVR1) is involved in tumorigenesis. However, the underlying molecular mechanisms of ACVR1 in gastric cancer (GC) and its association with Helicobacter pylori remained unclear. The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis
Huishan Sun et al.
EMBO reports, 22(10), e52537-e52537 (2021-08-31)
Cholesterol is essential for membrane biogenesis, cell proliferation, and differentiation. The role of cholesterol in cancer development and the regulation of cholesterol synthesis are still under active investigation. Here we show that under normal-sterol conditions, p53 directly represses the expression
Ying Huang et al.
Frontiers in physiology, 12, 697139-697139 (2021-09-08)
Our previous study found that acupuncture with low frequency electrical stimulation (Acu/LFES) prevents muscle atrophy by attenuation of protein degradation in mice. The current study examines the impact of Acu/LFES on protein synthesis. C57/BL6 mice received Acu/LFES treatment on hindlimb
Conditional knockout mice.
Ralf Kühn et al.
Methods in molecular biology (Clifton, N.J.), 209, 159-185 (2002-10-03)
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務