540216

PTP Inhibitor XVIII

The PTP Inhibitor XVIII, also referenced under CAS 1229246-07-4, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 同義詞: PTP Inhibitor XVIII, Protein Tyrosine Phosphatase Inhibitor XIII, 5-( E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII, Protein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII
• 經驗公式（希爾表示法）: C₁₉H₁₀BrF₆NO₃S
• CAS號碼: 1229246-07-4
• 分子量：: 526.25
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: light yellow
• 溶解度: DMSO: 25 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

描述

一般說明

A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC₅₀ = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Bhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett.19, 6161.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable