528110-M

PIH

A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class.

• 同義詞: PIH, pyridoxal isonicotinoyl hydrazone, Iron Chelator III
• 經驗公式（希爾表示法）: C₁₄H₁₄N₄O₃
• CAS號碼: 737-86-0
• 分子量：: 286.29
• MDL號碼: MFCD00763290
• 分類程式碼代碼: 12352200
• NACRES: NA.28

屬性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: solid
• 反應適用性: reagent type: chelator
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 5 mg/mL; slighlty acidic medium: soluble
• 儲存溫度: 2-8°C
• InChI: 1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,17,19H,8H2,1H3,(H,18,21)/b12-7+
• InChI 密鑰: HOYFGBFEIXEDEL-KPKJPENVSA-N

描述

一般說明

A cell-permeable, non-toxic tridendate iron (Fe³⁺) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.

A cell-permeable, non-toxic, iron (Fe³⁺) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.

其他說明

Buss, J.L., et al. 2002. Biochem. Pharmacol.64, 1689.
Thomas, S.R., et al. 2001. J. Immunol.166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta1523, 154.
Blaha, K., et al. 1998. Blood11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med.131, 306.
Richardson, D.R.,et al. 1995. Blood86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med.124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta802, 477.
Ponka, P., et al. 1979. FEBS Lett.97, 317.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable