5.08158
TGF-β
InSolution, ≥99%, 50 mM in DMSO, RI Kinase Inhibitor II, RepSox
同義詞:
InSolution TGF-β RI Kinase Inhibitor II, RepSox, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
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About This Item
推薦產品
品質等級
化驗
≥99% (HPLC)
形狀
liquid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
儲存溫度
−70°C
SMILES 字串
[nH]1ncc(c1c4nc(ccc4)C)c2nc3c(nccc3)cc2
InChI
1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChI 密鑰
LBPKYPYHDKKRFS-UHFFFAOYSA-N
一般說明
A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM).
生化/生理作用
Cell permeable: yes
Primary Target
ALK5
ALK5
Reversible: yes
Target IC50: 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&beta
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
外觀
A 50 mM (5 mg/348 µl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox (Cat. No. 616452) in DMSO.
重構
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilution.
其他說明
Ichida, J. K., et al. 2009. Cell Stem Cell5, 491.
Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.
Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
188.6 °F - (refers to pure substance)
閃點(°C)
87 °C - (refers to pure substance)
分析證明 (COA)
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