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Merck
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重要文件

5.08158

Sigma-Aldrich

TGF-β

InSolution, ≥99%, 50 mM in DMSO, RI Kinase Inhibitor II, RepSox

同義詞:

InSolution TGF-β RI Kinase Inhibitor II, RepSox, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

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About This Item

經驗公式(希爾表示法):
C17H13N5
CAS號碼:
分子量::
287.32
MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.77

品質等級

化驗

≥99% (HPLC)

形狀

liquid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

儲存溫度

−70°C

SMILES 字串

[nH]1ncc(c1c4nc(ccc4)C)c2nc3c(nccc3)cc2

InChI

1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

InChI 密鑰

LBPKYPYHDKKRFS-UHFFFAOYSA-N

一般說明

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM).

生化/生理作用

Cell permeable: yes
Primary Target
ALK5
Reversible: yes
Target IC50: 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&beta

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外觀

A 50 mM (5 mg/348 µl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox (Cat. No. 616452) in DMSO.

重構

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilution.

其他說明

Ichida, J. K., et al. 2009. Cell Stem Cell5, 491.
Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

188.6 °F - (refers to pure substance)

閃點(°C)

87 °C - (refers to pure substance)


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