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480001

Millipore

NDSB-195

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.

同義詞:

NDSB-195, Dimethylethylammonium Propane Sulfonate

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About This Item

經驗公式(希爾表示法):
C7H17NO3S
CAS號碼:
分子量::
195.28
分類程式碼代碼:
12611902
NACRES:
NA.21

品質等級

化驗

≥95% (TLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)

顏色

white

溶解度

water: soluble

運輸包裝

ambient

儲存溫度

15-25°C

一般說明

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Does not absorb significantly in the near-UV range. Easily removed by dialysis.

應用


  • Protein stabilizer, NDSB-195, enhances the dynamics of the β4 -α2 loop of ubiquitin.: This research explores how NDSB-195 stabilizes proteins by enhancing the dynamics of the β4-α2 loop of ubiquitin, providing insights into its mechanism of action as a protein stabilizer (Wang et al., 2016).

  • Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines.: The study demonstrates the effectiveness of NDSB-195 in suppressing the oligomerization of problematic compounds, showcasing its utility in biochemical and pharmaceutical applications (Mizukoshi et al., 2015).

  • Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor.: This article discusses the interaction of NDSB-195 with acidic fibroblast growth factor, emphasizing its role in preventing protein aggregation during biochemical processes (Xiang et al., 2008).

  • Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA.: The study uses NDSB-195 in the preparation and crystallization process, enhancing the stability and quality of the DNA-binding domain crystals for X-ray diffraction analysis (Suwa et al., 2008).

警告

Toxicity: Irritant (B)

其他說明

Goldberg, M.E., et al. 1996. Folding & Design 1, 21.
Vuillard, L., et al. 1995. Anal. Biochem. 230, 290.
Vuillard, L., et al. 1995. Biochem. J. 305, 337.
Vuillard, L., et al. 1994. FEBS Lett.353, 294.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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