444605

Melittin

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca²⁺-dependent manner.

• 同義詞: Melittin
• 經驗公式（希爾表示法）: C₁₃₁H₂₂₉N₃₉O₃₁
• CAS號碼: 37231-28-0
• 分子量：: 2846.46
• MDL號碼: MFCD00076868
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 描述: Merck USA index - 14, 5824
• 化驗: >97% (HPLC)
• 形狀: lyophilized
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 溶解度: water: 1 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N1(C(CCC1)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(CC)C)C(=O)NC(CO)C(=O)NC(Cc2c3c([nH]c2)cccc3)C(=O)NC(C(CC)C)C(=O)NC(CCCCN)C(=O)NC(CCCN\C(=N\[H])\N)C(=O)NC(CCCCN)C(=O)NC(CCCN\C(=N\[H])\N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)N)C(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC
• InChI: 1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)
• InChI 密鑰: VDXZNPDIRNWWCW-UHFFFAOYSA-N

描述

一般說明

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca²⁺-dependent manner, activates phospholipase A₂, and inhibits protein kinase C (IC₅₀ = 5-7 µM) by binding to the catalytic domain in a Mg²⁺-ATP sensitive manner. A stimulator of G_iα and G₁₁α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca²⁺-binding proteins. Activates G_iα-1 and G₁₁α activities and inhibits G_s activity.

生化／生理作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C

包裝

Yes

警告

Toxicity: Standard Handling (A)

序列

H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂

其他說明

Fukushima, N., et al. 1998. Peptides19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun.133, 256.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3