跳轉至內容
Merck
全部照片(1)

重要文件

384620

Sigma-Aldrich

Honokiol

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.

同義詞:

Honokiol, 5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C18H18O2
CAS號碼:
分子量::
266.33
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

描述

Merck USA index - 14, 4742

化驗

≥98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 10 mg/mL
ethanol: soluble

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

Oc1c(cc(cc1)c2c(ccc(c2)CC=C)O)CC=C

InChI

1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

InChI 密鑰

FVYXIJYOAGAUQK-UHFFFAOYSA-N

一般說明

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.
The active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.

生化/生理作用

Cell permeable: no
Primary Target
Anti-angiogenic, anti-tumor and anxiolytic properties
Product does not compete with ATP.
Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Bai, X., et al. 2003. J. Biol. Chem.278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol.63, 1641.
Son, H.J., et al. 2000. Planta Med.66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod.61, 135.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

CorrosionEnvironment

訊號詞

Danger

危險聲明

危險分類

Aquatic Chronic 2 - Eye Dam. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務