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重要文件

P1499

Sigma-Aldrich

紫檀芪

≥97% (HPLC), solid

同義詞:

紫檀, 3,5-二甲氧基-4'-羟基茋, 4-[(1E)-2-(3,5-二甲氧基苯基)乙烯基] 苯酚

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About This Item

經驗公式(希爾表示法):
C16H16O3
CAS號碼:
分子量::
256.30
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥97% (HPLC)

形狀

solid

儲存條件

protect from light

溶解度

DMSO: >20 mg/mL
H2O: insoluble

儲存溫度

2-8°C

SMILES 字串

COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1

InChI

1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

InChI 密鑰

VLEUZFDZJKSGMX-ONEGZZNKSA-N

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一般說明

紫檀芪(反式-3,5-二甲氧基-4-羟基芪)抗氧化剂是白藜芦醇的类似物,存在于蓝莓、树木和几种葡萄中。

應用

紫檀芪已用于:
  • 研究其抗氧化应激活性以及在核转录因子E2相关因子2(Nrf2)-抗氧化反应元件(ARE)信号转导通路中的调节作用
  • 确定其对激素耐受性乳腺癌细胞雌激素受体α(ERα)转录激活的影响
  • 通过MTT(3-[4,5-二甲基噻唑-2-基]-2,5二苯基四氮唑溴化物)活力检测法研究其对人表皮样癌细胞(A-431)中2-氯乙基乙基硫醚(CEES)的细胞毒性的影响。

生化/生理作用

抗氧化、抗增殖、细胞凋亡诱导、抗高血糖、抗糖尿病。
紫檀芪对几种恶性肿瘤具有抗癌作用,因此可作为活性抗癌药物。在雌激素受体阳性和阴性乳腺癌细胞系中,它可激活细胞凋亡并抑制细胞活性。

注意

空气敏感性

象形圖

CorrosionEnvironment

訊號詞

Danger

危險聲明

危險分類

Aquatic Chronic 2 - Eye Dam. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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