352010
谷氨酰胺酶抑制剂，化合物968
Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.
同義詞:
谷氨酰胺酶抑制剂，化合物968, GAC抑制剂、GLS1抑制剂I、KGA抑制剂I、肾型谷氨酰胺酶抑制剂I、5-（3-溴-4-（二甲氨基）苯基）-2，2-二甲基-2，3，5，6-四氢苯并[a]菲啶-4（1H）-酮
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About This Item
推薦產品
品質等級
化驗
≥99% (HPLC)
形狀
powder
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
O=C(CC(C)(C)C1)C2=C1C3=C(NC2C4=CC(Br)=C(C=C4)N(C)C)C=CC5=C3C=CC=C5
InChI 密鑰
NVFRRJQWRZFDLM-UHFFFAOYSA-N
一般說明
一种细胞可渗透的苯并菲啶酮化合物，可作为线粒体谷氨酰胺酶活性的变构和可逆抑制剂，并抑制谷氨酰胺酶上调的成纤维细胞和肿瘤细胞中的生长和侵袭活性（稳定表达Dbl，Cdc42-F28L，Rac-F28L或RhoC-F30L突变体以及SKBR3和MDA-MB231癌症细胞中的IC50 ≤ 10 µM）。在P-493B异种移植小鼠模型中显示可有效缩小肿瘤大小（200 µg/inj. i.p.，12天）。也可以10 mM的DMSO溶液（货号506073）提供。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
其他說明
Wang, J.B., et al. 2010.Cancer Cell18, 207.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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