341501

FeTMPyP

Catalyzes the isomerization of peroxynitrite (ONOO⁻) to nitrate (NO3⁻) under physiological conditions and at realistic dose-derived concentrations (k_cat = 2.2 x 10⁶M⁻¹s⁻¹).

• 同義詞: FeTMPyP, 5,10,15,20-Tetrakis(N-methyl-4ʹ-pyridyl)porphinato Iron (III) Chloride, Fe ^IIITMPyP(Cl)
• 經驗公式（希爾表示法）: C₄₄H₃₆Cl₅FeN₈
• 分子量：: 909.92
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥90% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: brown
• 溶解度: water: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

Catalyzes the isomerization of peroxynitrite (ONOO^–) to nitrate (NO₃^–) under physiological conditions and at realistic dose-derived concentrations (K_cat = 2.2 x 10⁶ M^-1s^-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals (O₂^·). Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH·) radicals. FeTMPyP can also serve as a potential for drug detoxification of reactive oxygen species (ROS).

生化／生理作用

Cell permeable: no

Kcat = 2.2 x 106 M-1s-1 in catalyzing the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions

Primary Target
Peroxynitrite (ONOO-)

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

其他說明

Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.46, 703.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable