240896

Cystatin C, Human Urine

A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane.

• 同義詞: Post γ-globulin
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (SDS-PAGE)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 溶解度: 0.1 M sodium acetate, pH 4.5: soluble
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

描述

一般說明

A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Rapidly and tightly inhibits papain (K_i = 0.26 nM) and cathepsin B (K_i = 4.4 nM). Thought to be linked to many disease processes including Alzheimer′s Disease, hereditary cerebral hemorrhage and lung cancer.

生化／生理作用

Cell permeable: no

Primary Target
Cysteine protease

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

外觀

Lyophilized from 20 mM NH₄HCO₃.

準備報告

Prepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

重構

Following reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.

其他說明

Hall, A., et al. 1998. Biochemistry37, 4071.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest.56, 409.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable