236015

COX-2 Inhibitor V, FK3311

The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• 同義詞: COX-2 Inhibitor V, FK3311, 4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
• 經驗公式（希爾表示法）: C₁₅H₁₃F₂NO₄S
• CAS號碼: 116686-15-8
• 分子量：: 341.33
• MDL號碼: MFCD00876455
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: ethanol: 15 mg/mL; DMSO: 30 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: Fc1c(ccc(c1)F)Oc2c(ccc(c2)C(=O)C)N[S](=O)(=O)C
• InChI: 1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3
• InChI 密鑰: DIIYLGZNZGPXRR-UHFFFAOYSA-N

描述

一般說明

A cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC₅₀ = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC₅₀ = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Otani, Y., et al. 2007. J. Invest. Surg.20, 175.
Sunose, Y., et al. 2001. Transplant Proc.33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res.44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull.41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull.40, 2399.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable