23-036-M

UbcH6 Protein, active, 10 µg

Active, full length, recombinant human UbcH6. N-terminal HA, 6His-tagged. For use in Enzyme Assays. Functions as an E2 enzyme in ubiquitination assays.

• 同義詞: Ubiquitin-conjugating enzyme E2 E1, Ubiquitin-protein ligase E1, UBE2E1
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

屬性

• 生物源: human
• 品質等級: 100; 300
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable
• NCBI登錄號: NM_003341
• UniProt登錄號: P51965

描述

一般說明

Ubiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or a Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate.
UbcH6 has been shown to interact with a number of diverse E3 ligases, including RNF20/40, Trim32 and WWP2.

應用

Ubiquitination Cascade Comoponent: E2

Active, full length, recombinant human UbcH6. N-terminal HA, 6His-tagged. For use in Enzyme Assays. Functions as an E2 enzyme in ubiquitination assays.

外觀

Purified using immobilized metal affinity chromatography.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable