推薦產品
product name
组织蛋白酶G抑制剂I, The Cathepsin G Inhibitor I, also referenced under CAS 429676-93-7, controls the biological activity of Cathepsin G. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
品質等級
化驗
≥98% (HPLC)
形狀
solid
效力
53 nM IC50
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
DMSO: 5 mg/mL
methanol: soluble
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25)36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42,43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3,(H2,42,43,44)
InChI 密鑰
GNOZQRKYZJSIPZ-UHFFFAOYSA-N
一般說明
组织蛋白酶G的有效，选择性，可逆，竞争性非肽抑制剂[IC50=53 nM，Ki=63 nM]。弱抑制胰凝乳蛋白酶（Ki = 1.5 µM），弱抑制凝血酶，Xa因子，IXa因子，纤溶酶，胰蛋白酶，类胰蛋白酶，蛋白酶3和人白细胞弹性蛋白酶（IC50 >100 µM）。
组织蛋白酶G的有效，选择性，可逆，竞争性非肽抑制剂（IC50 = 53 nM，Ki = 63 nM）。弱抑制胰凝乳蛋白酶（Ki = 1.5 µM），对凝血酶，Xa因子，IXa因子，纤溶酶，胰蛋白酶，类胰蛋白酶，蛋白酶3和人白细胞弹性蛋白酶（IC50 >100 µM）没有任何明显的抑制作用。
生化／生理作用
主要靶标
组织蛋白酶G
组织蛋白酶G
产物不与ATP竞争。
可逆性：是
细胞渗透性：否
靶标Ki：63 nM，对于组织蛋白酶G
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻（-20°C）。储备液在-20°C条件下可稳定保存3个月。
其他說明
Greco, M.N., et al. 2002.J. Am. Chem. Soc.124, 3810.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Akmaral Assylbekova et al.
Pharmaceuticals (Basel, Switzerland), 15(5) (2022-05-29)
Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by comorbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein (SARS-CoV-2 S protein) to angiotensin-converting enzyme 2 (ACE2), along with proteolytic digestion of the S
Fabian Gärtner et al.
ACS omega, 5(43), 28233-28238 (2020-11-10)
During an immune response, cathepsin G (CatG) takes on the role of adaptive and innate immunity and the outcome depends on the localization of CatG. Soluble, cell surface-bound, or intracellular CatG is also responsible for pathophysiology conditions. We applied the
Niina Aaltonen et al.
Biological procedures online, 22, 6-6 (2020-03-20)
Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using fluorophosphonate (FP) probes has been a powerful
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Cancer immunology research, 9(7), 790-810 (2021-05-16)
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