211875

Captopril

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC₅₀ = 11 µM).

• 同義詞: Captopril, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
• 經驗公式（希爾表示法）: C₉H₁₅NO₃S
• CAS號碼: 62571-86-2
• 分子量：: 217.29
• MDL號碼: MFCD00168073
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (titration)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white to off-white
• 溶解度: water: 1 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• InChI 密鑰: FAKRSMQSSFJEIM-RQJHMYQMSA-N

描述

一般說明

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC₅₀ = ~ 320 nM).

An antihypertensive agent. Reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.

生化／生理作用

Cell permeable: no

Primary Target
ACE

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他說明

Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H341,H360F
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Muta. 2 - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable