178278

Apigenin

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

• 同義詞: Apigenin, 4ʹ,5,7-Trihydroxyflavone
• 經驗公式（希爾表示法）: C₁₅H₁₀O₅
• CAS號碼: 520-36-5
• 分子量：: 270.24
• MDL號碼: MFCD00006831
• 分類程式碼代碼: 12352212
• NACRES: NA.77

屬性

• 品質等級: 100
• 描述: Merck USA index - 14, 730
• 化驗: ≥98% (HPLC)
• 形狀: crystalline solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: yellow
• 溶解度: hot ethanol: 1 mg/mL; DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: [o]1c2c([c](cc1c3ccc(cc3)O)=O)c(cc(c2)O)O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• InChI 密鑰: KZNIFHPLKGYRTM-UHFFFAOYSA-N

描述

一般說明

A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44^mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G₂/M arrest and to induce morphological differentiation.

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G₂/M arrest and induces morphological differentiation.

生化／生理作用

Cell permeable: no

Primary Target
MAP kinase

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Irritant (B)

重構

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.

其他說明

Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun.212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett.87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun.204, 578.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3