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Key Documents

171262

Sigma-Aldrich

AMPK 激活剂 V,氨苯砜-Calbiochem

The AMPK Activator V, Ampkinone modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.

同義詞:

AMPK Activator V, Ampkinone, AKN, AMPK Signaling Activator V

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About This Item

經驗公式(希爾表示法):
C31H23NO6
CAS號碼:
分子量::
505.52
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.51

品質等級

化驗

≥98% (HPLC)

形狀

powder

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

yellow

溶解度

DMSO: 25 mg/mL

運輸包裝

wet ice

儲存溫度

2-8°C

SMILES 字串

OC1=C(OC)C=CC2=C1OC(C)(C)C3=C2C=CC4=C3C(N(C5=CC=C(C(C6=CC=CC=C6)=O)C=C5)C4=O)=O

一般說明

A cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Oh, S., et al. 2010. J. Med. Chem.53, 7405.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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