171259

AMPK 激活剂 III，DHPO-Calbiochem

The AMPK Activator III, DHPO modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

• 同義詞: AMPK Activator III, DHPO, 1-oxo-2-(2H-pyrrolium-1-yl)-1H-inden-3-olate, AMPK Signaling Activator III
• 經驗公式（希爾表示法）: C₁₃H₉NO₂
• 分子量：: 211.22
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: >95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: orange
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C

描述

一般說明

A cell-permeable AMPK activator (20 mg/kg/d i.p. for 21d) that has been shown to attenuate fasting blood glucose, improve glucose disposal, and correct dyslipidemia in genetic (leptin deficient, ob/ob) and dietary (high-fat-fed) mouse models of insulin resistance over controls. IP injections for 14 days increases skeletal muscle glucose uptake by > ~30% and ~70% compared to vehicle-treated lean and obese mice, respectively. Treatment with 100 µM of DHPO results in a small but significant AMPK (Thr¹⁷²) phosphorylation, and a concentration dependent increase in glucose uptake with a 2-fold increase over controls, in cultured myotubes. Furthermore, 20 nM Compound C demonstrates a 58% and 41% inhibition of DHPO-stimulated glucose up-take at concentrations of 50 µM and 100 µM DHPO, respectively.

警告

Toxicity: Standard Handling (A)

重構

Unstable in solution; reconstitute just prior to use.

其他說明

Kandadi, M.R., et al. 2009. Biochem. Pharmacol.79, 623.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable