124009
Akt Inhibitor III
The Akt Inhibitor III controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
同義詞:
Akt Inhibitor III, SH-6
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About This Item
經驗公式（希爾表示法）:
C28H57O9P
分子量：:
568.72
分類程式碼代碼:
12352200
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (NMR)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
white
溶解度
DMSO: 10 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
A phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
生化／生理作用
Cell permeable: yes
Primary Target
Akt
Akt
Product does not compete with ATP.
Reversible: yes
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重構
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Gills, J.J., et al. 2007. J. Biol. Chem.in press.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Li Li et al.
Haematologica (2021-10-08)
Platelet hyperreactivity and increased atherothrombotic risk are specifically associated with dyslipidemia. Peroxisome proliferator-activated receptor alpha (PPARα) is an important regulator of lipid metabolism. It was suggested to affect both thrombosis and hemostasis, yet the underlying mechanisms are not well understood.
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