1.00241

无水柠檬酸粉末

anhydrous powder, EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 330

• 同義詞: 2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid
• 線性公式: HOC(COOH)(CH₂COOH)₂
• CAS號碼: 77-92-9
• 分子量：: 192.12
• Beilstein: 782061
• MDL號碼: MFCD00011669
• 分類程式碼代碼: 12352106
• 酶號碼: E330
• 酶委員會索引編號: 201-069-1

屬性

• agency: BP; JP; Ph. Eur.; USP
• 品質等級: 500
• 法律遵循: FCC
• 蒸汽壓力: <0.1 hPa ( 20 °C)
• 產品線: EMPROVE^® ESSENTIAL
• 化驗: 99.5-100.5% substance (anhydrous) basis (alkalimetric)
• 形狀: fine powder
• 效力: 3000 mg/kg LD₅₀, oral (Rat)
• expl. lim.: 8 %, 65 °F
• pH值: 1.7 (20 °C, 100 g/L in H₂O)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• bp: 200 °C/1013 hPa (decomposition)
• mp: 153-159 °C (lit.)
• 溶解度: 1330 g/L
• 密度: 1.665 g/cm³ at 18 °C
• 正離子痕跡: Al: ≤0.2 ppm; As: ≤1 ppm; Hg: ≤1 ppm; Pb: ≤0.5 ppm; heavy metals (as Pb): ≤5 ppm
• 應用: liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• 儲存溫度: 2-30°C
• SMILES 字串: OC(=O)CC(O)(CC(O)=O)C(O)=O
• InChI: 1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
• InChI 密鑰: KRKNYBCHXYNGOX-UHFFFAOYSA-N

描述

一般說明

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

應用

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove^® Essential is citric acid present in its water-free, powder form.

法律資訊

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable