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Merck
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文件

07-728

Sigma-Aldrich

Anti-HRI Antibody

serum, Upstate®

同義詞:

Anti-HCR, Anti-HRI, Anti-LEMSPAD, Anti-hHRI

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

100

抗體表格

serum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

rabbit, human, mouse

製造商／商標名

Upstate®

技術

immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG

NCBI登錄號

NM_014413.2

UniProt登錄號

Q9BQI3

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... EIF2AK1(27102)
mouse ... Eif2Ak1(15467)

特異性

HRI

免疫原

6His-tagged fusion protein corres-ponding to residues 1-138 of mouse heme-regulated inhibitor (HRI)

應用

Detect HRI using this Anti-HRI Antibody validated for use in IP & WB.

品質

Routinely evaluated by immunoblot on lysates from mouse reticulocytes.

標靶描述

72kDa

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Maryam Rafie-Kolpin et al.
Biochemistry, 42(21), 6536-6544 (2003-05-28)
In heme deficiency, protein synthesis is inhibited by the activation of the heme-regulated eIF2alpha kinase (HRI) through its multiple autophosphorylation. Autophosphorylation sites in HRI were identified in order to investigate their functions. We found that there were eight major tryptic
Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation.
Anderson, Paul and Kedersha, Nancy
Cell Stress & Chaperones, 7, 213-221 (2002)
Takahiro Sakai et al.
Antioxidants (Basel, Switzerland), 10(9) (2021-09-29)
Lung fibrosis is the primary pathology in idiopathic pulmonary fibrosis and is considered to result from an increase in reactive oxygen species (ROS) levels in alveolar epithelial cells. However, the exact mechanism underlying lung fibrosis remains unclear and there is
The eIF-2alpha kinases and the control of protein synthesis.
de Haro, C, et al.
Faseb Journal, 10, 1378-1387 (1996)
J J Chen et al.
Trends in biochemical sciences, 20(3), 105-108 (1995-03-01)
Protein synthesis is regulated by the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF-2 alpha) in a variety of cells. At present, there are two distinct mammalian eIF-2 alpha kinases that have been cloned, the double-stranded-RNA-dependent eIF-2 alpha
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