跳轉至內容
Merck
全部照片(2)

重要文件

700040P

Avanti

desmosterol-d6

Avanti Research - A Croda Brand

同義詞:

24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C27H38OD6
CAS號碼:
分子量::
390.67
分類程式碼代碼:
12352100
NACRES:
NA.25

描述

cholesta-5,24-dien-3β-ol-d6

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (700040P-1mg)

製造商/商標名

Avanti Research - A Croda Brand

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.

應用

Desmosterol-d6 has been used:
  • as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
  • as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
  • for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

生化/生理作用

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.

包裝

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

也與該產品經常一起購買

儲存類別代碼

11 - Combustible Solids


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

抱歉,我們目前沒有在線上提供本產品的COA

如果您需要協助,請聯絡 客戶支援

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Valerie A Villareal et al.
ACS chemical biology, 11(7), 1827-1833 (2016-04-30)
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These observations suggest a model in which desmosterol

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務