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重要文件

700116P

Avanti

7-去氢胆甾醇-d7

7-dehydrocholesterol-d7, powder

同義詞:

111110

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About This Item

經驗公式(希爾表示法):
C27H37D7O
CAS號碼:
分子量::
391.68
分類程式碼代碼:
41141804
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (700116P-1mg)

製造商/商標名

Avanti Research - A Croda Brand 700116P

運輸包裝

dry ice

儲存溫度

−70°C

一般說明

7-脱氢胆固醇(7-DHC)是一种胆固醇前体,位于基底表皮角质形成细胞中。7DHC在紫外光B存在下发生光解生成维生素原D3。脱氢胆固醇还原酶(DHCR7)催化7-DHC的C(7-8)双键还原为胆固醇。7-脱氢胆固醇是7-脱氢胆固醇的氘代衍生物。

應用

7-脱氢胆固醇-d7已被用于:
  • 作为内标物:加标衣藻CC-125脂质提取物进行质谱分析
  • 用于培养细胞氧化甾醇分析的液相色谱-质谱(LC-MS)中
  • 用于气相色谱/质谱(GC/MS)分析用于处理和标记SRD-1细胞(中国仓鼠卵巢(CHO)突变细胞系)

生化/生理作用

7-脱氢胆固醇(7-DHC)用作微生物维生素D3生产的前体。 7-脱氢胆固醇还原酶(DHCR7)功能受损导致7-DHC积累,并与Smith-Lemli-Opitz综合征(SLOS)有关。

包裝

5 mL琥珀色玻璃螺旋盖小瓶(700116P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Andrzej T Slominski et al.
PloS one, 4(2), e4309-e4309 (2009-02-05)
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats, pigs, rabbits and dogs with production
Hanul Kim et al.
Frontiers in microbiology, 6, 54-54 (2015-03-12)
Concern about global warming has prompted an intense interest in developing economical methods of producing biofuels. Microalgae provide a promising platform for biofuel production, because they accumulate high levels of lipids, and do not compete with food or feed sources.
Galya Staneva et al.
Langmuir : the ACS journal of surfaces and colloids, 32(6), 1591-1600 (2016-01-20)
7-Dehydrocholesterol, an immediate metabolic predecessor of cholesterol, can accumulate in tissues due to some metabolic abnormalities, causing an array of symptoms known as Smith-Lemli-Opitz syndrome. Enrichment of cellular membranes with 7-dehydrocholesterol interferes with normal cell-signaling processes, which involve interaction between
Hisako Akiyama et al.
Journal of lipid research, 57(11), 2061-2072 (2016-11-03)
To date, sterylglucosides have been reported to be present in various fungi, plants, and animals. In bacteria, such as Helicobacter pylori, proton NMR spectral analysis of isolated 1-O-cholesteryl-β-d-glucopyranoside (GlcChol) demonstrated the presence of an α-glucosidic linkage. By contrast, in animals
Josi Herron et al.
Current protocols in toxicology, 78(1), e65-e65 (2018-10-16)
Cholesterol and cholesterol-derived oxysterols are critical for embryonic development, synapse formation and function, and myelination, among other biological functions. Indeed, alterations in levels of cholesterol, sterol precursors, and oxysterols result in a variety of developmental disorders, emphasizing the importance of

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