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Key Documents

D7631

Sigma-Aldrich

5,5-二甲基噁唑烷-2,4-二酮

同義詞:

DMO, NSC 30152, 二甲双酮

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About This Item

經驗公式(希爾表示法):
C5H7NO3
CAS號碼:
分子量::
129.11
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

形狀

powder

品質等級

mp

77-80 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

CC1(C)OC(=O)NC1=O

InChI

1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)

InChI 密鑰

JYJFNDQBESEHJQ-UHFFFAOYSA-N

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應用

作为反应物,参与以下反应:
  • 苯并环镍或萘环镍β氧杂氮杂氯配合物的合成
  • 用作组织蛋白酶K抑制剂

参与药理学研究的分子包括:
  • 抗癫痫药生物等效仿制药的鉴定
  • 筛选将能量代谢从线粒体呼吸转变为糖酵解的药物
  • 溶解总胆管囊肿/胰胆管连接不良患者的蛋白塞

象形圖

Exclamation markHealth hazard

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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J M Squirrell et al.
Biology of reproduction, 64(6), 1845-1854 (2001-05-23)
In early cleavage stage hamster embryos, the inability to regulate intracellular pH (pHi) properly is associated with reduced developmental competence in vitro. The disruption of mitochondrial organization is also correlated with reduced development in vitro. To determine the relationship between
Bengt R Danielsson et al.
Reproductive toxicology (Elmsford, N.Y.), 24(1), 42-56 (2007-06-16)
In the adult organism, it is well established that hypoxia followed by reperfusion may be fatal and result in generation of reactive oxygen species (ROS) and subsequent tissue damage. There is also considerable evidence that temporary decrease or interruption in
G A Biagini et al.
The Journal of biological chemistry, 276(31), 29157-29162 (2001-04-12)
Giardia intestinalis is a pathogenic fermentative parasite, which inhabits the gastrointestinal tract of animals and humans. G. intestinalis trophozoites are exposed to acidic fluctuations in vivo and must also cope with acidic metabolic endproducts. In this study, a combination of
Hemal Mehta et al.
The Cochrane database of systematic reviews, 4, CD011599-CD011599 (2018-04-19)
The combination of steroid and anti-vascular endothelial growth factor (VEGF) intravitreal therapeutic agents could potentially have synergistic effects for treating diabetic macular oedema (DMO). On the one hand, if combined treatment is more effective than monotherapy, there would be significant
F Dubé et al.
Developmental biology, 190(1), 41-54 (1997-10-23)
Intracellular pH (pHi) measurements were performed in surf clam (Spisula solidissima) oocytes before and after artificial activation or fertilization [evidenced by germinal vesicle breakdown (GVBD)] by the dimethyloxazolidinedione (DMO) and 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCECF) methods. Results using both methods showed increases of

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