936596

1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride

≥95%

• 同義詞: 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
• 經驗公式（希爾表示法）: C₁₇H₂₀N₄O₄ · xHCl
• CAS號碼: 2162120-73-0
• 分子量：: 344.37 (free base basis)
• MDL號碼: MFCD31730833
• 分類程式碼代碼: 12161600
• NACRES: NA.22

屬性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder or crystals
• 顏色: light yellow to yellow
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCN)C3C2=O)CC1

描述

應用

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. A basic building block for making protein degrader library.

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其他說明

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable