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重要文件

767344

Sigma-Aldrich

Poly(D,L-lactide)

greener alternative

average Mn 20,000 (NMR), PDI ≤1.3

同義詞:

PDLA, PLA, polyDL-lactide

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About This Item

分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

crystals

品質等級

分子量

average Mn 20,000 (NMR)

環保替代產品特色

Design for Energy Efficiency
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

降解時間

<6 months

mp

320-350 °C

蛋白質二硫鍵異構酶

≤1.3

環保替代類別

儲存溫度

2-8°C

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一般說明

We are committed to bringing you Greener Alternative Products, which belongs to one of the four categories of greener alternatives. This is an enabling product that belongs to a family of high-performance bio-based polymers that are essential for developing efficient, low-cost, and environmentally friendly renewable energy solutions. Click here for more information.

應用

Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Synthesis of Shape Amphiphiles Based on Functional Polyhedral Oligomeric Silsesquioxane End-Capped Poly(L-Lactide) with Diverse Head Surface Chemistry
Zhang W B, et al.
Macromolecules, 44(8), 2589-2596 (2011)
Poly(lactide)-block-Poly(HEMA) Block Copolymers: An Orthogonal One-Pot Combination of ROP and ATRP, Using a Bifunctional Initiator
Wolf F F, et al.
Macromolecules, 42(15), 5622-5628 (2009)
Preparation of Protein-Loaded Poly(L-Lactide) Microspheres by Solution-Enhanced Dispersion by Supercritical CO2
Chen A Z, et al.
Journal of Biomimetics, Biomaterials, and Tissue Engineering, 11, 93-100 (2011)

文章

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

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Global Trade Item Number

庫存單位GTIN
767344-5G4061832921549

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