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Merck
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764590

Sigma-Aldrich

聚 L -丙交酯

average Mn 5,000, PDI ≤1.2

同義詞:

PLLA, 聚乳酸, L-乳酸聚合物, PLA,聚(L-L-乳酸)

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About This Item

線性公式:
H(C3H4O2)nOCH3
分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

solid

光學活性

[α]22/D -147°, c = 0.5% in chloroform

分子量

average Mn 5,000

降解時間

>3 years

轉變溫度

Tm 149-154 °C

蛋白質二硫鍵異構酶

≤1.2

儲存溫度

2-8°C

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一般說明

聚(L-丙交酯)是一种旋光性强、机械性能良好的半结晶聚合物。它主要用于合成可降解聚合物,用于骨科设备,牙科应用,作为支架用于自体移植的新皮肤、伤口覆盖、吻合系统和支架。它们是可生物降解的,因为聚酯骨架通过简单水解降解,形成无毒化合物。

應用

药物递送包括涂覆纳米颗粒;端基官能化;大分子引发剂或嵌段前体。

特點和優勢

高初始强度,良好的强度保持性和高达 70% 的高结晶度,这反过来又导致非常缓慢的降解速率。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Effect of poly (ethylene glycol)-block- poly (L-lactide) on the poly [(R)-3-hydroxybutyrate]/poly (L-lactide) blends
Yoon, J. S., Lee, W. S., Kim, K. S., Chin, I. J., Kim, M. N., & Kim, C.
Eur. Polymer J., 36(2), 435-442 (2000)
Chemical synthesis of polylactide and its copolymers for medical applications
Bendix, D.
Polymer Degradation and Stability, 59(1), 129-135 (1998)
Synthesis and thermal properties of novel star-shaped poly (l-lactide)s with starburst PAMAM-OH dendrimer macroinitiator.
Zhao, Y. L., Cai, Q., Jiang, J., Shuai, X. T., Bei, J. Z., Chen, C. F., & Xi, F.
Polymer, 43(22), 5819-5825 (2002)
Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)

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Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

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