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Merck
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文件

725765

Sigma-Aldrich

2-甲基-4-异噻唑啉-3-酮

95%

同義詞:

2-甲基-3(2H)-异噻唑啉酮

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About This Item

經驗公式(希爾表示法):
C4H5NOS
CAS號碼:
分子量::
115.15
Beilstein:
606203
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21

化驗

≥94.0% (GC)
95%

形狀

lumps

雜質

≤5% water

SMILES 字串

CN1SC=CC1=O

InChI

1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3

InChI 密鑰

BEGLCMHJXHIJLR-UHFFFAOYSA-N

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應用

  • Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide.:研究水蚤对2-甲基-4-异噻唑啉-3-酮的不同种内敏感度,说明这些差异后潜藏的生化机制。该发现为环境安全性评估带来重要视点(Kim et al., 2023)。
  • Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration.:该研究评估2-甲基-4-异噻唑啉-3-酮对两栖动物再生过程的影响,有助了解它的生物作用和潜在毒性(Delos Santos et al., 2016)。
  • T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.:该综述有讨论2-甲基-4-异噻唑啉-3-酮诱发的接触性皮炎,提供有关皮肤科应用和安全评估的宝贵信息(Knackstedt and Zug, 2015)。

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

安全危害

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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A Spawn et al.
Neuroscience, 205, 194-204 (2012-01-17)
Methylisothiazolinone (MIT) is a commonly used biocide known to be neurotoxic in vitro. Brief exposure of cortical neurons in culture to MIT results in increased neurodegeneration, whereas chronic exposure of developing neurons in culture to low concentrations of MIT has
Christina L Burnett et al.
International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22)
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble
Eleanor Higgins et al.
Dermatitis : contact, atopic, occupational, drug, 24(2), 73-76 (2013-03-12)
The isothiazolinones methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) are the active ingredients in a frequently used preservative in cosmetic, household, and industrial products. This study reviewed our department's cases of allergic contact dermatitis caused by MCI/MI, outlining their clinical presentation and possible
Mari Paz Castanedo-Tardana et al.
Dermatitis : contact, atopic, occupational, drug, 24(1), 2-6 (2013-01-24)
The preservative methylisothiazolinone (MI) is the American Contact Dermatitis Society Contact Allergen of the Year for 2013. Because the use of MI in cosmetics and toiletries in the United States rises, MI exposure also rises. Although it might seem likely
M D Lundov et al.
The British journal of dermatology, 165(6), 1178-1182 (2011-07-23)
In the early 2000s the preservative methylisothiazolinone (MI) was released as an individual preservative for industrial products and, in 2005, it was permitted for use in cosmetic products. Up until then MI had been used only in combination with methylchloroisothiazolinone

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