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Key Documents

384410

Sigma-Aldrich

三甲基氯硅烷 溶液

1.0 M in THF

同義詞:

Trimethylchlorosilane

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About This Item

線性公式:
(CH3)3SiCl
CAS號碼:
分子量::
108.64
Beilstein:
1209232
MDL號碼:
分類程式碼代碼:
12352302
PubChem物質ID:
NACRES:
NA.22

形狀

liquid

品質等級

濃度

1.0 M in THF

密度

0.88 g/mL at 25 °C

SMILES 字串

C[Si](C)(C)Cl

InChI

1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

InChI 密鑰

IJOOHPMOJXWVHK-UHFFFAOYSA-N

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一般說明

Chlorotrimethylsilane (TMSCl) is a silylating agent employed in the silylation of alcohols, amines, carboxylic acids, thiols, and other functional groups. Silyl group serves as a protecting group for these original functional groups.

應用

Chlorotrimethylsilane (TMSCl) can be used as a reagent:
  • To synthesize allenylsilane via carbolithiation of conjugated enynes with aryllithium.
  • In the reductive coupling of aldehydes and ketones to produce corresponding 1,2 diols in the presence of zirconocene dichloride and magnesium.
  • To prepare 4,4′-bis(trimethylsilyl)bicyclohexyl-2,2′-diene from 1,3-cyclohexadiene by reductive disilylation reaction.

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 2 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3

標靶器官

Respiratory system

安全危害

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

-4.0 °F - closed cup

閃點(°C)

-20 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


分析證明 (COA)

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Zirconocene dichloride-catalyzed pinacol coupling of aromatic aldehydes and ketones
Lakshmi Kantam M, et al.
Synthetic Communications, 36(10), 1437-1445 (2006)
Carbolithiation of conjugated enynes with aryllithiums in microflow system and applications to synthesis of allenylsilanes
Tomida Y, et al.
Organic Letters, 11(16), 3614-3617 (2009)
Ainara Sistiaga et al.
PloS one, 9(6), e101045-e101045 (2014-06-26)
Neanderthal dietary reconstructions have, to date, been based on indirect evidence and may underestimate the significance of plants as a food source. While zooarchaeological and stable isotope data have conveyed an image of Neanderthals as largely carnivorous, studies on dental
Mark Sundberg et al.
Langmuir : the ACS journal of surfaces and colloids, 22(17), 7302-7312 (2006-08-09)
We have previously described the efficient guidance and unidirectional sliding of actin filaments along nanosized tracks with adsorbed heavy meromyosin (HMM; myosin II motor fragment). In those experiments, the tracks were functionalized with trimethylchlorosilane (TMCS) by chemical vapor deposition (CVD)
Malin Persson et al.
Langmuir : the ACS journal of surfaces and colloids, 26(12), 9927-9936 (2010-03-27)
In the in vitro motility assay, actin filaments are propelled by surface-adsorbed myosin motors, or rather, myosin motor fragments such as heavy meromyosin (HMM). Recently, efforts have been made to develop actomyosin powered nanodevices on the basis of this assay

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