374539

氯丙二酸二甲酯

94%

• 同義詞: 1,3-Dimethyl 2-chloropropanedioate, 2-Chloro-malonic acid dimethyl ester, Chloropropanedioic acid dimethyl ester, Dimethyl α-chloromalonate, Dimethyl 2-chloromalonate, Dimethyl 2-chloropropanedioate
• 線性公式: ClCH(COOCH₃)₂
• CAS號碼: 28868-76-0
• 分子量：: 166.56
• Beilstein: 1768415
• EC號碼: 249-275-0
• MDL號碼: MFCD00042837
• 分類程式碼代碼: 12352100
• PubChem物質ID: 24863315
• NACRES: NA.22

屬性

• 化驗: 94%
• 形狀: liquid
• 雜質: 4-5% dimethyl dichloromalonate
• 折射率: n20/D 1.437 (lit.)
• bp: 105-106 °C/19 mmHg (lit.)
• 密度: 1.305 g/mL at 25 °C (lit.)
• 官能基: chloro; ester
• SMILES 字串: COC(=O)C(Cl)C(=O)OC
• InChI: 1S/C5H7ClO4/c1-9-4(7)3(6)5(8)10-2/h3H,1-2H3
• InChI 密鑰: LNBQBURECUEBKZ-UHFFFAOYSA-N

描述

一般說明

Dimethyl chloromalonate (dimethyl 2-chloromalonate) is a dialkyl 2-substituted malonate. Carbanions of dimethyl chloromalonate are reported to react with naphthoquinone derivatives, via vicarious nucleophilic substitution or oxidative nucleophilic substitution of hydrogen processes. Dimethyl chloromalonate is reported to react with hydroquinone and monosubstituted hydroquinones to afford 2-oxido-benzo[b]furan derivatives. Synthesis of dimethyl 2-chloromalonate, via chlorination of dimethyl malonate has been reported.

應用

Dimethyl chloromalonate is suitable for use in the synthesis of 4,5,6-trichloropyrimidine. It may be used in the stereoselective synthesis of highly functionalized nitrocyclopropanes. It may be used in one-pot synthesis of tetra-alkoxycarbonylallylidenetriphenylphosphoranes.

安全資訊

• 象形圖: GHS05
• 訊號詞: Danger
• 危險聲明: H314
• 防範說明: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• 危險分類: Skin Corr. 1B
• 儲存類別代碼: 8A - Combustible corrosive hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 224.6 °F - closed cup
• 閃點（°C）: 107 °C - closed cup
• 個人防護裝備: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter