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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 85 kDa
物種活性
human
濃度
~1 mg/mL
技術
indirect immunofluorescence: 5-10 μg/mL using MCF7 cells fixed with paraformaldehyde-Triton
western blot: 0.5-1 μg/mL using A431 cell lysates
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... XRCC1(7515)
mouse ... Xrcc1(22594)
rat ... Xrcc1(84495)
一般說明
X-ray repair cross-complementing group 1 (XRCC1) is a testis enriched protein. It is considered as a DNA repair gene.
免疫原
synthetic peptide corresponding to amino acids 615-633 of human XRCC1, conjugated to KLH via an N-terminal added cysteine residue. The immunizing peptide is identical in mouse and rat.
應用
Anti-XRCC1 antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- indirect immunofluorescence and telomere FISH (TEL-FISH)
- protein detection
- western analysis
生化／生理作用
X-ray repair cross-complementing group 1 (XRCC1) is a molecular scaffold protein that coordinates the assembly of repair complexes at damaged sites. XRCC has been shown to physically interact with several enzymes known to be involved in the repair of SSBs, including DNA ligase IIIa, DNA polymerase b, APE1, polynucleotide kinase (PNK), poly (ADP-ribose), polymerases 1 and 2 (PARP-1 and 2) and others. It participates in the DNA base excision repair (BER) pathway.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
XRCC1 deficiency correlates with increased DNA damage and male infertility
Singh V, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 839, 1-8 (2019)
XRCC1 deficiency correlates with increased DNA damage and male infertility
Singh V, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 839 (2019)
Characterization of oxidative guanine damage and repair in mammalian telomeres
Wang Z, et al.
PLoS Genetics, 6(5), e1000951-e1000951 (2010)
XRCC1 polymorphism and overall survival in ovarian cancer patients treated with platinum-based chemotherapy: A systematic review and MOOSE-compliant meta-analysis
Zhang Z, et al.
Medicine, 97(45) (2018)
X-ray repair cross complementing protein 1 in base excision repair
Hanssen-Bauer A, et al.
International Journal of Molecular Sciences, 13(12), 17210-17229 (2012)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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