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形狀
solid
品質等級
顏色
yellow
溶解度
DMSO: >10 mg/mL
H2O: insoluble
儲存溫度
−20°C
SMILES 字串
O.C[C@]12Cc3cn4c(nc3C[C@@H]1CC[C@@H]5[C@@H]2CC[C@@]6(C)[C@H]5CC[C@@]6(O)C#C)nc7ccccc47
InChI
1S/C29H33N3O.H2O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24;/h1,5-8,17,19-22,33H,9-16H2,2-3H3;1H2/t19-,20+,21-,22-,27-,28-,29-;/m0./s1
InChI 密鑰
RGVGINOANKXLLR-GCGDSGHKSA-N
基因資訊
rat ... Tacr1(24807)
生化/生理作用
WIN 51708 hydrate is a non-peptide NK1 tachykinin receptor antagonist.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Journal of medicinal chemistry, 35(2), 374-378 (1992-01-24)
Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further biochemical (kinetic and Scatchard analyses) and pharmacological evaluation (substance P-induced plasma extravasation and salivation in the rat) of a representative
Molecular pharmacology, 41(4), 772-778 (1992-04-01)
125I-Bolton-Hunter-substance P (125I-BH-SP) binding properties of three novel classes of neurokinin-1 (NK-1) receptor antagonists were investigated in tissues derived from humans, guinea pigs, and rats. 125I-BH-SP was shown to bind to a single class of binding sites, with similar dissociation
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