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Merck

S6317

Sigma-Aldrich

L-萝卜硫素

≥95% (HPLC), oil

别名:

(R)-1-异硫氰酸基-4-(甲亚磺酰基)-丁烷, 4-甲基亚磺酰基丁基异硫氰酸酯

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About This Item

经验公式(希尔记法):
C6H11NOS2
分子量:
177.29
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥95% (HPLC)

形狀

oil

光學活性

[α]/D -70 to -90°, c = 1.0 in chloroform-d

顏色

light yellow

溶解度

DMSO: >5 mg/mL

儲存溫度

−20°C

SMILES 字串

CS(=O)CCCCN=C=S

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3/t10-/m1/s1

InChI 密鑰

SUVMJBTUFCVSAD-SNVBAGLBSA-N

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應用

L-萝卜硫素可用于研究小鼠原代前脂肪细胞6和小鼠巨噬细胞RAW 264.7细胞系 中Nrf2介导的信号转导。7

生化/生理作用

L-萝卜硫素是II期解毒酶的有效选择性诱导剂,且具有抗癌特性。在十字花科蔬菜(包括西兰花)中发现的有机硫化合物。
萝卜硫素是十字花科蔬菜中的一种抗癌、抗微生物和抗糖尿病化合物。3,4 它可诱导产生解毒酶,例如引起异生素转化的醌还原酶和谷胱甘肽S-转移酶。萝卜硫素还可增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性。它通过抑制LPS介导的iNOS、COX-2、IL-1β和TNF-α.的表达来调节炎症反应。3,5

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves


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