推荐产品
生物源
bovine erythrocytes
產品線
BioUltra
化驗
≥98% (SDS-PAGE)
形狀
essentially salt-free, lyophilized powder
儲存條件
(Tightly closed. Dry)
技術
western blot: suitable
雜質
salt, essentially free
溶解度
water: 1 mg/mL, clear, colorless
UniProt登錄號
儲存溫度
2-8°C
基因資訊
bovine ... LOC(101902760)
正在寻找类似产品? 访问 产品对比指南
一般說明
研究领域：癌症
泛素是一种高度保守的调控蛋白。它存在于所有真核细胞中，在包括酵母、人类和植物在内的所有生命形式中几乎是相同的。泛素结构包含7个赖氨酸残基和一个N末端，这些都是泛素化的靶点。
泛素是一种高度保守的调控蛋白。它存在于所有真核细胞中，在包括酵母、人类和植物在内的所有生命形式中几乎是相同的。泛素结构包含7个赖氨酸残基和一个N末端，这些都是泛素化的靶点。
This product is from bovine red blood cells. It is not a recombinant product. The production process is considered proprietary, however it includes heat treatment as well as purification by chromatography and dialysis.
應用
来自牛红细胞的泛素已用于研究外源性泛素在慢性β肾上腺素受体（β-AR）刺激的心肌重构中的作用。它还被用作测试核因子kappa-B激酶亚基β（IKKβ）泛素化的抑制剂。
来自牛红细胞的泛素可用于体外泛素化检测。该产品还可以用作蛋白质印迹的标记物。
来自牛红细胞的泛素可用于体外泛素化检测。该产品还可以用作蛋白质印迹的标记物。
生化／生理作用
泛素化是泛素蛋白与底物蛋白结合的翻译后修饰过程。泛素化在细胞凋亡、蛋白质加工、免疫反应、DNA修复等生物学过程中对细胞信号传导的调控起着重要作用。泛素化通过泛素-蛋白酶体途径介导蛋白质降解。泛素化作用涉及多种细胞信号传导途径。多聚泛素化可调节炎症信号传导途径中NF-κ-B抑制剂α（IkB-α）的信号激活。在很多疾病中都可观察到泛素水平的升高，比如寄生虫病和过敏性疾病、酒精性肝病、ii型糖尿病、2-微球蛋白淀粉样变tβ2-微球蛋白淀粉样变以及慢性血液透析等。
準備報告
牛红细胞中的泛素可以1 mg/ml的量溶于水中，产生澄清无色的溶液。
抗體
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
A L Schwartz et al.
Annual review of medicine, 50, 57-74 (1999-03-12)
The ubiquitin-proteasome pathway plays a pivotal role in the degradation of short-lived and regulatory proteins important in a variety of basic cellular processes, including regulation of the cell cycle, modulation of cell surface receptors and ion channels, and antigen presentation.
Frederik Lermyte et al.
The Analyst, 142(18), 3388-3399 (2017-08-16)
Electron transfer dissociation (ETD) is becoming increasingly important in mass spectrometry-based analysis of peptides and proteins. Supplemental collisional activation of undissociated electron transfer products can significantly increase fragmentation yield and sequence coverage, but hydrogen rearrangements - specifically, transfer of a
Frederik Lermyte et al.
Journal of the American Society for Mass Spectrometry, 28(1), 69-76 (2016-08-09)
Owing to its versatility, electron transfer dissociation (ETD) has become one of the most commonly utilized fragmentation techniques in both native and non-native top-down mass spectrometry. However, several competing reactions-primarily different forms of charge reduction-occur under ETD conditions, as evidenced
The ubiquitin system for protein degradation.
A Hershko et al.
Annual review of biochemistry, 61, 761-807 (1992-01-01)
Errol W Robinson et al.
Analytical chemistry, 80(19), 7508-7515 (2008-08-30)
Field asymmetric waveform ion mobility spectrometry (FAIMS) has emerged as an analytical tool of broad utility, especially in conjunction with mass spectrometry. Of particular promise is the use of FAIMS and 2-D ion mobility methods that combine FAIMS with conventional
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门