推荐产品
生物源
bovine erythrocytes
產品線
BioUltra
化驗
≥98% (SDS-PAGE)
形狀
essentially salt-free, lyophilized powder
儲存條件
(Tightly closed. Dry)
技術
western blot: suitable
雜質
salt, essentially free
溶解度
water: 1 mg/mL, clear, colorless
UniProt登錄號
儲存溫度
2-8°C
基因資訊
bovine ... LOC(101902760)
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一般說明
研究领域:癌症
泛素是一种高度保守的调控蛋白。它存在于所有真核细胞中,在包括酵母、人类和植物在内的所有生命形式中几乎是相同的。泛素结构包含7个赖氨酸残基和一个N末端,这些都是泛素化的靶点。
泛素是一种高度保守的调控蛋白。它存在于所有真核细胞中,在包括酵母、人类和植物在内的所有生命形式中几乎是相同的。泛素结构包含7个赖氨酸残基和一个N末端,这些都是泛素化的靶点。
應用
来自牛红细胞的泛素已用于研究外源性泛素在慢性β肾上腺素受体(β-AR)刺激的心肌重构中的作用。它还被用作测试核因子kappa-B激酶亚基β(IKKβ)泛素化的抑制剂。
来自牛红细胞的泛素可用于体外泛素化检测。该产品还可以用作蛋白质印迹的标记物。
来自牛红细胞的泛素可用于体外泛素化检测。该产品还可以用作蛋白质印迹的标记物。
生化/生理作用
泛素化是泛素蛋白与底物蛋白结合的翻译后修饰过程。泛素化在细胞凋亡、蛋白质加工、免疫反应、DNA修复等生物学过程中对细胞信号传导的调控起着重要作用。泛素化通过泛素-蛋白酶体途径介导蛋白质降解。泛素化作用涉及多种细胞信号传导途径。多聚泛素化可调节炎症信号传导途径中NF-κ-B抑制剂α(IkB-α)的信号激活。在很多疾病中都可观察到泛素水平的升高,比如寄生虫病和过敏性疾病、酒精性肝病、ii型糖尿病、2-微球蛋白淀粉样变tβ2-微球蛋白淀粉样变以及慢性血液透析等。
準備報告
牛红细胞中的泛素可以1 mg/ml的量溶于水中,产生澄清无色的溶液。
抗體
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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