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Merck

T9449

Sigma-Aldrich

D-(+)-海藻糖 二水合物

≥99% (HPLC), from starch

别名:

α,α-海藻糖, α-D-吡喃葡萄糖基-α-D-吡喃葡萄糖苷

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About This Item

经验公式(希尔记法):
C12H22O11 · 2H2O
CAS号:
分子量:
378.33
Beilstein:
5322018
EC號碼:
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:
NACRES:
NA.25

生物源

Manihot esculenta root (Cassava)

品質等級

化驗

≥99% (HPLC)

形狀

powder

光學活性

[α]20/D 174 to 186 °, c = 1.0% (w/v) in water

技術

HPLC: suitable

雜質

7.3-11.6% water (Karl Fischer)

顏色

white

mp

97-99  °C

溶解度

water: 50 mg/mL, clear, colorless to very faintly yellow

儲存溫度

room temp

SMILES 字串

[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI 密鑰

DPVHGFAJLZWDOC-PVXXTIHASA-N

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一般說明

海藻糖是一种由两个葡萄糖单位通过1-1α键结合而形成的非还原性糖。这种二糖广泛存在于原核生物和真核生物等微生物中。

應用

D-(+)-海藻糖二水化物已被用于:
  • 用于海藻糖测试以稳定药物产品
  • 作为海藻糖/蔗糖溶液的成分用于制备J-聚集体(J-aggregate)
  • 用于制备模拟蜂蜜糖混合物(SHSC)以研究其对蛋白质化学和热稳定性的影响

生化/生理作用

海藻糖是一种1-α(二糖)糖,它有助于植物和动物抵御长期的脱水。海藻糖可用作各种细胞冷冻培养基中的冷冻保护剂。它是一种主要的碳源,也是一种在应对渗透胁迫和热休克时积累的相容性溶质。

其他說明

为了全面了解我们针对客户研究提供的各种二糖产品,建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Theresa Cloutier et al.
The journal of physical chemistry. B, 122(40), 9350-9360 (2018-09-15)
The CHARMM36 carbohydrate parameter set did not adequately reproduce experimental thermodynamic data of carbohydrate interactions with water or proteins or carbohydrate self-association; thus, a new nonbonded parameter set for carbohydrates was developed. The parameters were developed to reproduce experimental Kirkwood-Buff
Alan Twomey et al.
International journal of pharmaceutics, 487(1-2), 91-100 (2015-04-19)
In frozen and lyophilized systems, the biological to be stabilized (e.g. therapeutic protein, biomarker, drug-delivery vesicle) and the cryo-/lyo-protectant should be co-localized for successful stabilization. During freezing and drying, many factors cause physical separation of the biological from the cryo-/lyo-protectant
Sabine Ullrich et al.
Journal of pharmaceutical sciences, 104(6), 2040-2046 (2015-04-03)
The importance of cake adhesion to the inside vial wall during lyophilization of amorphous trehalose cakes was determined by using hydrophobized vials. The degrees of cake shrinkage and cracking were determined independently by photographic imaging of the cake top surface
Joachim Schaefer et al.
International journal of pharmaceutics, 489(1-2), 124-130 (2015-05-06)
The inactivation of catalase during spray-drying over a range of outlet gas temperatures could be closely represented by the Arrhenius equation. From this an activation energy for damage to the catalase could be calculated. The close fit to Arrhenius suggests
Anke Sass et al.
Drug development and industrial pharmacy, 40(6), 749-757 (2013-04-20)
The spray-drying behaviour of 16 water-miscible organic solvents on a bench-scale machine (Büchi B290 with inert loop) was determined under mild-to-moderate process conditions, namely inlet gas temperature of 130 °C and liquid feed flow rate of ≤3 mL/min. The solvents with boiling

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