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T7513

Sigma-Aldrich

凝血酶 来源于牛血浆

lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280 = 19.5)

别名:

IIa 因子

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About This Item

CAS号:
9002-04-4
EC 号:
3.4.21.5 (BRENDA, IUBMB)
EC號碼:
232-648-7
MDL號碼:
MFCD00166053
分類程式碼代碼:
12352204
NACRES:
NA.54

形狀

lyophilized powder

品質等級

200

比活性

≥2,000 NIH units/mg protein (E1%/280 = 19.5)

分子量

heavy chain ~33 kDa
light chain ~5 kDa

UniProt登錄號

P00735

應用

diagnostic assay manufacturing

儲存溫度

−20°C

基因資訊

cow ... F2(280685)

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生化／生理作用

丝氨酸蛋白酶，选择性断开纤维蛋白原中的精氨酸-甘氨酸键，形成纤维蛋白以及纤维蛋白肽 A 和 B。

單位定義

活性以NIH单位表示，通过与NIH凝血酶参考标准品直接对比确定。

外觀

从生理盐水柠檬酸钠缓冲液（pH 6.5）冻干

分析報告

基于 Biggs 改性法的 NIH 分析过程使用 0.2mL 稀释血浆（由血浆与等量生理盐水混合制得）作为底物，以及 0.1mL 凝血酶样品（在含 1% 白蛋白缓冲液中保持稳定）。只使用 15-25 秒之间的凝血时间分析凝血酶浓度。
活性是通过与一种K批次的NIH凝血酶参考标准品进行直接比较而得到并以NIH单位进行表达的。

其他說明

查看更多关于 凝血酶的信息， 请访问 www.sigma-aldrich.com/enzymeexplorer。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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U Seligsohn
Haemophilia : the official journal of the World Federation of Hemophilia, 18 Suppl 4, 161-165 (2012-06-29)
For patients affected by severe inherited platelet dysfunctions, e.g. Glanzmann thrombasthenia (GT) or Bernard-Soulier syndrome (BSS), platelet transfusion is frequently needed for controlling spontaneous bleeding, and is always needed when trauma occurs or surgery is performed. For the mild-to-moderate bleeding
J Y Chueh et al.
AJNR. American journal of neuroradiology, 32(7), 1237-1244 (2011-05-21)
Mechanical behavior of the thromboembolus is one of the key factors that determine the efficacy of thrombectomy devices for revascularization in AIS. We characterized the mechanical properties and composition of thromboemboli from clinical cases and compared them with commonly used
B Bijina et al.
Saudi journal of biological sciences, 18(3), 273-281 (2011-07-01)
Protease inhibitors are well known to have several applications in medicine and biotechnology. Several plant sources are known to return potential protease inhibitors. In this study plants belonging to different families of Leguminosae, Malvaceae, Rutaceae, Graminae and Moringaceae were screened
Andrea Stöhr et al.
Journal of molecular and cellular cardiology, 63, 189-198 (2013-07-31)
Myosin-binding protein C (Mybpc3)-targeted knock-in mice (KI) recapitulate typical aspects of human hypertrophic cardiomyopathy. We evaluated whether these functional alterations can be reproduced in engineered heart tissue (EHT) and yield novel mechanistic information on the function of cMyBP-C. EHTs were
N J Royle et al.
Somatic cell and molecular genetics, 13(3), 285-292 (1987-05-01)
The gene for human prothrombin, or factor II (F2) has been assigned to 11p11-q12 by the combined use of a panel of somatic cell hybrid DNAs and in situ hybridization, using both cDNA and genomic probes. In addition, the cDNA
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