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产品名称
水蛭素 来源于蛭类, lyophilized powder, ≥1,500 ATU/mg protein (ATU = antithrombin units)
生物源
animal (Hirudo verbana)
品質等級
100
200
形狀
lyophilized powder
比活性
≥1,500 ATU/mg protein (ATU = antithrombin units)
分子量
7 kDa
溶解度
pyridine: soluble
water: soluble
儲存溫度
2-8°C
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一般說明
水蛭素是一种 7kDa 大小的酸性蛋白，含有 65 个氨基酸残基，等电点为 3.5-4.0。它未被糖基化，不含色氨酸、精氨酸和甲硫氨酸残基。在 pH 2-12 和高达 80°C 的温度下化学性质稳定。
生化／生理作用
水蛭素这种抗凝血剂是可溶性和血凝块结合性凝血酶最强效的天然抑制剂。它与凝血酶的结合具有高亲和力，可覆盖其表面积的 20% 以上，并封闭活性位点和外部位点 I（纤维蛋白原和 PAR 识别位点）。水蛭素可阻滞血栓生长及血小板活化。它在人体血流中不发生代谢反应，通过肾脏过滤原样排除。
The anticoagulant, hirudin, is the most potent natural inhibitor of both soluble and clot-bound thrombin. It forms a high-affinity 1:1 complex with thrombin, occluding both the proteolytic site and exosite I (fibrinogen and PAR recognition site). Hirudin blocks thrombus growth and platelet activation, and has been suggested as the clinically preferred anticoagulant (over heparin and citrate) for its specific mode of action and absence of side effects. It is not metabolized in the bloodstream of humans and is eliminated unchanged via kidney filtration.
單位定義
One unit (ATU) will neutralize one NIH unit of thrombin at 37 °C, based on direct comparison to an NIH thrombin reference standard.
分析報告
Protein determined by Lowry.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Sarah E Sartain et al.
Journal of immunology (Baltimore, Md. : 1950), 196(2), 832-845 (2015-12-18)
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy with severe renal injury secondary to an overactive alternative complement pathway (AP). aHUS episodes are often initiated or recur during inflammation. We investigated gene expression of the surface complement regulatory proteins
Mengzhou Xue et al.
Brain : a journal of neurology, 132(Pt 1), 26-36 (2008-09-06)
Proteases such as matrix metalloproteinases (MMPs) and thrombin are implicated in intracerebral haemorrhage (ICH) but their interactions amongst one another and interdependency remain to be defined. The latter is important since proteases acting through different mechanisms to inflict neurotoxicity would
Yaoming Wang et al.
Stroke, 40(5), 1864-1869 (2008-12-06)
Activated protein C (APC), a protease with anticoagulant and cytoprotective activities, protects neurons and endothelium from ischemic injury. Drotrecogin-alfa activated, a hyperanticoagulant form of human recombinant APC, is currently being studied in patients with ischemic stroke. How changes in APC
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