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Merck
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Key Documents

H2042

Sigma-Aldrich

Histone H2A human

别名:

Histone, Human

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.25

生物源

human

品質等級

重組細胞

expressed in E. coli

形狀

liquid

濃度

1 mg/mL

UniProt登錄號

應用

cell analysis

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... H2AC20(8338)

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一般說明

Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.

應用

Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.

生化/生理作用

Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.

外觀

Supplied in 20 mM Na3PO4, pH 7.0, 0.3 M NaCl and 1 mM EDTA

象形圖

Health hazard

訊號詞

Danger

危險聲明

防範說明

危險分類

Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Khoa N Pham et al.
The journal of physical chemistry. B, 125(19), 4977-4986 (2021-05-12)
Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem nonlinear and linear
Apurva Bhardwaj et al.
International journal of molecular sciences, 22(1) (2021-01-07)
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is an essential protein that regulates cellular processes such as cell proliferation, apoptosis, and differentiation. It is known to bind with several proteins to carry out various cellular functions. In this study, we
Luis Donis-Maturano et al.
SpringerPlus, 4, 161-161 (2015-04-18)
Neutrophils are one the earliest, crucial innate defenses against innumerable pathogens. Their main microbicidal activities include phagocytosis and degranulation, with many pharmacologically active molecules contributing to inflammation. Recently, a novel antimicrobial mechanism was discovered; the Neutrophil Extracelullar Traps (NETs) formed

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