推荐产品
一般說明
组蛋白是含有H3、H4、H2A和H2B的八聚体蛋白。它是DNA是围绕其缠绕形成核小体结构的核心蛋白。核心组蛋白包含球状结构域。每个蛋白在其N端均由碱性氨基酸组成。H2A在其C末端具有一个额外的氨基酸，形成组蛋白尾巴。核小体结构在染色质浓缩过程中通过接头组蛋白稳定。
應用
小牛胸腺中的组蛋白已用于：
- 在甲基转移酶反应混合物中进行甲基转移酶测定
- 在体外结合试验中，探讨了MORF4（4号染色体上的死亡率因子）-15号染色体上相关基因（MRG15）与组蛋白的潜在结合
- 在体外共培养试验中刺激肝脏驻留的Kupffer细胞
生化／生理作用
核心组蛋白参与组蛋白-组蛋白各种相互作用并维持核小体DNA的组织。组蛋白尾巴有助于形成更高阶的核小体结构。染色质纤维的整体结构和作用受组蛋白修饰的调节。
特點和優勢
不要将Sigma“类型”名称与Luck及其同事使用的“分级”名称混淆。
準備報告
未分级的全组蛋白
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3
Zhang P, et al.
Nucleic Acids Research, 34(22), 6621-6628 (2006)
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury
Huang H, et al.
Journal of Immunology, 191(5), 2665-2679 (2013)
Juan-Carlos Cabrera et al.
Glycobiology, 20(6), 775-786 (2010-03-05)
Plant cell walls undergo remodeling during growth and development and are the first target of many invading pathogens. Acidic pectin (homogalacturonans) binds calcium and forms chain dimers called egg boxes and even multimers at higher calcium ion concentrations. Chitosan, the
Yannick Tauran et al.
Scientific reports, 9(1), 5816-5816 (2019-04-11)
By means of Silicon Nano Tweezers (SNTs) the effects on the mechanical properties of λ-phage DNA during interaction with calf thymus nucleosome to form an artificial chromatin analog were measured. At a concentration of 100 nM, a nucleosome solution induced a
Adam F Kebede et al.
Nature structural & molecular biology, 24(12), 1048-1056 (2017-10-24)
Histones are highly covalently modified, but the functions of many of these modifications remain unknown. In particular, it is unclear how histone marks are coupled to cellular metabolism and how this coupling affects chromatin architecture. We identified histone H3 Lys14
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门