推荐产品
生物源
Streptomyces luteosporeus
品質等級
化驗
≥95% (HPLC)
形狀
solid
溶解度
DMSO: 0.90 - 1.10 mg/ml, clear, yellow
抗生素活性譜
fungi
作用方式
enzyme | inhibits
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
CCC(=O)NC1=C2SSC=C2N(C)C1=O
InChI
1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
InChI 密鑰
UGZYFXMSMFMTSM-UHFFFAOYSA-N
應用
Thiolutin has been used as a polymerase II inhibitor:
- to study its effects on yeast cells to calculate transcript half-life
- to study its effects on transcription during germination in budding yeast
- to study its effects on cell adhesion in zebrafish
生化／生理作用
Sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.
準備報告
Thiolutin dissolves in DMSO at 0.90 - 1.10 mg/ml to yield a clear, yellow solution.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
A Joshi et al.
Antimicrobial agents and chemotherapy, 22(4), 541-547 (1982-10-01)
Spontaneous mutants of Salmonella typhimurium isolated in our laboratory from thiolutin-containing tryptone agar plates are partially resistant to thiolutin in enriched media. In minimal media, they are not resistant. The mutants are not temperature sensitive but fail to support the
RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.
A O'Neill et al.
Antimicrobial agents and chemotherapy, 44(11), 3163-3166 (2000-10-19)
A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase beta-subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin
K Minamiguchi et al.
International journal of cancer, 93(3), 307-316 (2001-07-04)
Recent studies have shown that integrin alpha v beta 3, a receptor for vitronectin, plays an important role in tumor-induced angiogenesis and tumor growth and that antagonists of alpha v beta 3 inhibit angiogenic processes including endothelial cell adhesion and
J Abrahão-Neto et al.
Biochemistry, 34(33), 10456-10462 (1995-08-22)
We examined the effects of inhibition of mitochondrial functions on the expression of two nuclear genes encoding the extracellular cellobiohydrolase I (cbh1) and endoglucanase I (egl1) of the cellulase system of the filamentous fungus Trichoderma reesei. The cbh1 and egl1
Jörg Grigull et al.
Molecular and cellular biology, 24(12), 5534-5547 (2004-06-01)
Using DNA microarrays, we compared global transcript stability profiles following chemical inhibition of transcription to rpb1-1 (a temperature-sensitive allele of yeast RNA polymerase II). Among the five inhibitors tested, the effects of thiolutin and 1,10-phenanthroline were most similar to rpb1-1.
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