C2389

Cerulenin

from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor

• 别名: Helicocerin, (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
• 经验公式（希尔记法）: C₁₂H₁₇NO₃
• CAS号: 17397-89-6
• 分子量: 223.27
• Beilstein: 4140423
• EC號碼: 241-424-8
• MDL號碼: MFCD00083595
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24892323
• NACRES: NA.77

属性

• product name: Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens
• 生物源: Cephalosporium caerulens
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• mp: 93 °C
• 溶解度: acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow
• 抗生素活性譜: fungi
• 作用方式: enzyme | inhibits
• 儲存溫度: −20°C
• SMILES 字串: C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
• InChI: 1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1
• InChI 密鑰: PTNNGEBMCNMENY-JIVMHGEESA-N
• 基因資訊: human ... FASN(2194)

说明

一般說明

Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.

應用

Cerulenin has been used:

• as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity
• as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
• as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves