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生物源
human
重組細胞
expressed in HEK 293 cells
籤條
6-His tagged (C-terminus)
化驗
≥95% (SDS-PAGE)
形狀
lyophilized powder
分子量
calculated mol wt 20.2 kDa
observed mol wt 28-33 kDa (DTT-reduced. Protein migrates due to glycosylation. Arg 29 is the predicted N-terminus.)
包裝
pkg of 10 μg
雜質
<1 EU/μg endotoxin (LAL test)
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... PLGF(5228)
一般說明
Placental growth factor (PLGF) exists in two isoforms namely PLGF1 and PLGF2. This protein is a homodimeric glycoprotein with molecular weight of 46–50kDa and is a member of the VEGF (vascular endothelial growth factor) subfamily. PLGF is encoded by the gene mapped to human chromosome 14q24-q31 regions. PLGF is expressed mainly in the placental trophoblast during pregnancy and is also present in various other tissues such as the villous trophoblast.
生化／生理作用
PLGF might enhance the production of peripheral blood mononuclear cell-vascular endothelial growth factor (PBMC-VEGF). Consequently, PlGF might facilitate VEGF production in the inflammatory joint. Soluble fms related tyrosine kinase 1 (Flt-1), which is considered to be an anti-angiogenic factor interacts with and inhibit the activity of PLGF. Therefore, PLGF level is lowered and the Flt-1 level is increased in placental tissue of women with pre-eclampsia (PE). PLGF is associated with the pathogenesis of rheumatoid arthritis (RA) and various other arthropathies. PLGF acts as a ligand for VEGFR-1 and is implicated in various physiological functions such as tumor angiogenesis, wound healing and hematopoietic progenitors recruitment.
外觀
Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
重構
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
PlGF blockade does not inhibit angiogenesis during primary tumor growth.
Bais C
Cell, 141(1), 166-177 (2010)
Role of placenta growth factor (PIGF) in human extravillous trophoblast proliferation, migration and invasiveness.
Athanassiades A and Lala PK
Placenta, 19(7), 465-473 (1998)
Placenta growth factor (PlGF) induces vascular endothelial growth factor (VEGF) secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid.
Bottomley MJ
Clinical and Experimental Immunology, 119(1), 182-188 (2000)
Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders.
Khalil A
PLoS ONE, 3(7), e2766-e2766 (2008)
Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively.
M G Mattei et al.
Genomics, 32(1), 168-169 (1996-02-15)
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