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生物源
mouse
重組細胞
expressed in E. coli
化驗
≥90% (SDS-PAGE)
形狀
lyophilized
效力
>200 ng/mL ED50
分子量
~18.0 kDa
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
endotoxin, tested
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... Vegfc(22341)
一般說明
VEGF-C (vascular endothelial growth factor-C) is a member of the VEGF family of structurally related proteins. The gene encoding this protein is localized on mouse chromosome 8. The product here (VEGF-C from mouse) is a 129 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain. Mouse VEGF-C exhibits about 85% homology with human and 97% homology with rat VEGF-C.
生化／生理作用
VEGF-C (vascular endothelial growth factor-C) has a role in lymphangiogenesis. It functions via the VEGF receptor-3 (VEGFR-3). Studies have shown that lymphatic endothelial cells do not form sprouting capillaries without VEGF-C. It has also been observed that this protein stimulates tumor lymphangiogenesis in xenotransplanted and transgenic mouse models of cancer.
外觀
Lyophilized from acetic solution with 50 μg BSA per 1 μg VEGF-C.
重構
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors.
Tuomela J
BMC Cancer, 9, 362-362 (2009)
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Karkkainen MJ
Nature Immunology, 5(1), 74-80 (2004)
Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator.
Lliersch R
International Journal of Oncology, 41(6), 2073-2078 (2012)
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites.
Hirakawa S
Blood, 109(3), 1010-1017 (2007)
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease.
Holmes DI and Zachary I
Genome Biology, 6(2), 209-209 (2005)
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