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Merck

545996

Sigma-Aldrich

L-硒代胱胺基乙酸

95%, for peptide synthesis

别名:

(R,R)-3,3′-二硒基-双(2-氨基丙酸), L-硒代胱氨酸

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About This Item

线性分子式:
CO2HCH(NH2)CH2(Se)2CH2CH(NH2)CO2H
CAS号:
分子量:
334.09
Beilstein:
1969559
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.22

product name

L-硒代胱胺基乙酸, 95%

化驗

95%

形狀

powder or crystals

光學活性

[α]20/D −28°, c = 1 in NaOH

反應適用性

reaction type: solution phase peptide synthesis

mp

224.5-229.5 °C (lit.)

應用

peptide synthesis

儲存溫度

2-8°C

SMILES 字串

N[C@@H](C[Se][Se]C[C@H](N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

InChI 密鑰

JULROCUWKLNBSN-IMJSIDKUSA-N

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應用

硒基-L-胱氨酸可用于以下物质的合成:
  • 生物活性硒醇化合物。
  • 非天然硒化二氨基酸。

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Novel selenium-containing non-natural diamino acids
Caputo R, et al.
Tetrahedron Letters, 48(8), 1425-1427 (2007)
Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of ?-elimination reactions in rat renal cytosol
Andreadou I, et al.
Journal of Medicinal Chemistry, 39(10), 2040-2046 (1996)
I Andreadou et al.
Journal of medicinal chemistry, 39(10), 2040-2046 (1996-05-10)
Eighteen Se-substituted selenocysteine derivatives were synthesized as potential kidney selective prodrugs which can be activated by renal cysteine conjugate beta-lyase to selenium-containing chemoprotectants or antitumor agents. Selenocysteine derivatives with aliphatic and benzylic Se-substituents were synthesized by reducing selenocystine to selenocysteine
Andrzej Gawor et al.
Animals : an open access journal from MDPI, 10(5) (2020-05-13)
Identification and quantification of the selenium species in biological tissues is imperative, considering the need to properly understand its metabolism and its importance in various field of sciences, especially nutrition science. Although a number of studies deals with the speciation
Tianfeng Chen et al.
The international journal of biochemistry & cell biology, 41(3), 666-676 (2008-08-23)
The role of selenium as potential cancer chemopreventive and chemotherapeutic agents has been supported by epidemiological, preclinical and clinical studies. Although cell apoptosis has been evidenced as a critical mechanism mediating the anticancer activity of selenium, the underlying molecular mechanisms

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