SRP0701

TAU-441 (1-421) Protein

recombinant

• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 重組細胞: expressed in E. coli
• 化驗: 70-95% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~60 kDa
• 濃度: 0.2 μg/μL
• 登錄號: P10636-8
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... MAPT(4137)

说明

應用

Useful for kinase assay and Western blot.

生化／生理作用

Recombinant human tag-free Tau-441 (1-421) was expressed in E. coli cells. Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules ⁽¹⁾. Deposits of Alzheimer′s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, ß-amyloid precursor protein (ßAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system ⁽²⁾.

重構

Formulated in 50mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

儲存和穩定性

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable