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Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Danielle Stoll et al.
Physiological reports, 7(11), e14105-e14105 (2019-06-06)
The kidney is an important target of the renin-ANG-aldosterone system (RAAS). To date, several studies have demonstrated the existence of a local RAAS in various tissues, including the renal tissue. The mineralocorticoid aldosterone is known to play a critical role
Charles E Evans et al.
Acta neuropathologica, 139(3), 485-502 (2020-01-27)
Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of later life dementia, including Alzheimer's disease (AD). The classical renin-angiotensin system (cRAS), a physiological regulator of blood pressure, functions independently within the brain and is overactive in AD. cRAS-targeting
A P O Leite et al.
Journal of cellular physiology, 234(12), 22809-22818 (2019-05-28)
Diabetes mellitus and its complications have become a major health concern in Western countries. Increased activity of the intrarenal renin-angiotensin system (RAS) contributes to diabetic nephropathy (DN). We previously reported that in mesangial cells, the high glucose concentration (HG) leads
Xiaomiao Zhang et al.
Archives of biochemistry and biophysics, 672, 108061-108061 (2019-07-30)
Autophagy exerts a dual role in promoting cell death or survival. Recent studies have shown that it may play an important role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). It was also suggested that angiotensin converting enzyme 2 (ACE2) may
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