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化驗
≥98% (HPLC)
形狀
powder
顏色
faint yellow to dark orange
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
OC(C(C=C1)=CC=C1/C=C(SC2=S)\C(N2CC3=CC=CC(C(F)(F)F)=C3)=O)=O
InChI
1S/C19H12F3NO3S2/c20-19(21,22)14-3-1-2-12(8-14)10-23-16(24)15(28-18(23)27)9-11-4-6-13(7-5-11)17(25)26/h1-9H,10H2,(H,25,26)/b15-9+
InChI 密鑰
DJTINRHPPGAPLD-OQLLNIDSSA-N
生化／生理作用
CY-09 是一种NLRP3炎性体抑制剂。CY-09 直接与 NLRP3 NACHT 结构域的 ATP 结合基序结合，并抑制其 ATP 酶活性，从而阻断 NLRP3 炎性体的组装和激活。在小鼠模型中，CY-09 对 2 型糖尿病和冷冻吡啶相关自身炎症综合征 （CAPS） 有治疗作用，这是由 NLRP3 的功能获得性突变（gain-of-function mutation）引起的。
NLRP3炎性体抑制剂
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Matthew S J Mangan et al.
Nature reviews. Drug discovery, 17(8), 588-606 (2018-07-22)
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- and pyrin domain-containing 3). Once activated, NLRP3 nucleates the assembly of an inflammasome, leading
Jianlin Qiao et al.
Haematologica, 103(9), 1568-1576 (2018-05-26)
In addition to their hemostatic function, platelets play an important role in regulating the inflammatory response. The platelet NLRP3 inflammasome not only promotes interleukin-1β secretion, but was also found to be upregulated during platelet activation and thrombus formation in vitro
Hua Jiang et al.
The Journal of experimental medicine, 214(11), 3219-3238 (2017-10-13)
The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome activation, but compounds directly and specifically targeting NLRP3 are still not available, so it
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