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Merck

SML1795

Sigma-Aldrich

替诺福韦

≥98% (HPLC)

别名:

(R)-9-(2-膦酰乙氧基丙基)腺嘌呤, (R)-PMPA

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About This Item

经验公式(希尔记法):
C9H14N5O4P
分子量:
287.21
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D -20 to -26°, c = 0.5 in 1 M HCl

顏色

white to beige

溶解度

H2O: 2 mg/mL, clear (warmed)

儲存溫度

−20°C

SMILES 字串

OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O

InChI

1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1

InChI 密鑰

SGOIRFVFHAKUTI-ZCFIWIBFSA-N

生化/生理作用

替诺福韦是一种核苷酸类似物逆转录酶抑制剂(nRTI),可导致DNA转录过早终止。替诺福韦是一种用于HIV治疗和预防的抗逆转录病毒药物。
替诺福韦的口服生物利用度较低。因此,它可以作为称为替诺福韦地索普西富马酸盐的前药。一旦摄入,替诺福韦地索普西富马酸盐可被水解成替诺福韦并被磷酸化。然后将其掺入病毒DNA中,导致链终止。替诺福韦对乙型肝炎病毒也有效。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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B L Robbins et al.
Antimicrobial agents and chemotherapy, 42(3), 612-617 (1998-03-28)
Bis(isopropyloxymethylcarbonyl) 9-R-(2-phosphonomethoxypropyl)adenine [bis(POC)PMPA] has been identified as a novel prodrug of PMPA. The anti-human immunodeficiency virus activity of bis(POC)PMPA was >100-fold greater than that of PMPA in both an established T-cell line and primary peripheral blood lymphocytes. This improved efficacy
Kevin R Robertson et al.
AIDS (London, England), 30(15), 2315-2321 (2016-06-23)
The objective was to determine whether maraviroc (MVC) has unique neurocognitive benefits in the context of initial antiretroviral therapy (ART). Randomized, double-blind, placebo-controlled, 48-week trial. Participants were enrolled in US AIDS Clinical Trials Group clinical trial sites. Total 262 ART-naive
Tracy P Trang et al.
Expert opinion on drug safety, 15(9), 1287-1294 (2016-07-09)
Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors approved as pre-exposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). Prophylactic TDF-based regimens have been shown to reduce the risk of HIV infection by 74 to 92% among

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